The Spectradyne nCS2 – High resolution nanoparticle analysis in a new design

The nCS2 by Spectradyne LLC is the follow-up model of the classic nCS1. Due to a mor innovative design with an optimized cartridge-interface,  measurements of particle-size and -count in the size range 50 nm to 10 µm are now even faster and easier. 

It operates on the basis of the Microfluidic Resistive Pulse Sensing (MRPS), measuring suspensions of arbitrary polydispersity and particle type in a truly orthogonal method to light-based techniques within minutes. In contrary to the majority of light-based methods, the nCS2 delivers high-resolution particle distributions, instead of ensemble distributions. Measurements are accomplished with as little as 3 µL of suspension.


How it works

The nCS2 uses Microfluidic Resistive Pulse Sensing (MRPS) to deliver high resolution nanoparticle size and concentration. Like resistive pulse sensing, it uses an electrical method. The conducting fluid is electrically biased by voltage-bias electrodes, which causes an electric current to flow through the analyte, the fluidic resistor and the nanoconstriction. The passage of a particle through the nanoconstriction will cause the electrical resistance of the constriction to change. This leads to a change in the sensing voltage, which is proportional to particle size. 

The nCS2 uses 5 different cartridges with different size nanoconstrictions, each optimized for a different size range. This enables the nCS2 to deliver high resolution particle sizes and concentrations for particles ranging 50 nm to 10 µm. 


Key features of the Spectradyne nCS2 

  • Electrical nanoparticle sizing and counting
  • Fast, precise & quantitative 
  • No cross-contamination (use of disposable cartridges)
  • Only 3 µL of sample required (10 µL for 10k cartridges)


  • Detection of protein aggregation
  • Extracellular vesicle/exosome 
  • Liposome and lipid nanoparticle (LNP) analysis
  • Gene therapy and nanomedicine
  • Industrial nanoparticle analysis


Spectradyne nCS2 Specifications

Method Microfluidic Resistive Pulse Sensing (MRPS) / Coulter principle
Particle Size Range  50 nm to 10 μm in diameter
Particle Concentration Range approx. 104 — 1012 particles/mL
Max. particle detection rate approx. 10,000 particles/s
Dimensions Benchtop unit: 50 cm wide × 50 cm deep × 23 cm high; Power supply unit: 30 cm wide × 40 cm deep × 15 cm high
Weight ~20 kg
Accessories  Windows Laptop with Spectradyne Tools software (included)