Fluid Imaging Technologies manufactures the FlowCam® family of innovative, imaging-based particle analysis systems used for research and quality control applications in a variety of markets worldwide. The FlowCam® technology was the first to combine the capabilities of a flow cytometer with a digital imaging microscope to make particle identification quicker and easier. With applications in phytoplankton and zooplankton research, algae cultivation, municipal water, biopharmaceutical formulations, oil and gas, superabrasives, and many other markets, Fluid Imaging Technologies continues to lead the way in imaging particle analysis.
These flow imaging microscopes measure 40+ physical parameters from 2D microscope images to give information on the size and shape of particles in a liquid. As the fluid flows through the flow cell past the camera, the particles are “frozen” using flash illumination and a clear, high resolution image is captured. Each picture is then transferred to FlowCam’s proprietary VisualSpreadsheet® software where physical parameters are measured from each image and data analyses can be run.
FlowCam® flow imaging microscopes and particle analyzers offer the following key features:
Spectradyne has developed a revolutionary instrument for measuring the concentration and size of sub-micron particles: the nCS1TM. The instrument uses a new, microfluidic implementation of the Resistive Pulse Sensing technique that is fast, easy-to-use, and practical for routine industrial use. In life science industries, the nCS1 is saving time by detecting protein aggregation earlier and enabling better research by quantifying biological nanoparticles (e.g., Exosomes) more accurately. Other impact areas include nanomedicine, virology, cosmetics and non-life science industries such as paints, inks, and semiconductor processing.
Spectradyne’s Microfluidic Resistive Pulse Sensing (MRPSTM) method is an electrical technique for counting and sizing nanoparticles. As a non-optical technique, MRPS is truly orthogonal to light scattering-based methods such as Nanoparticle Tracking Analysis (NTA) or Dynamic Light Scattering (DLS) and delivers accurate concentration measurements of nanoparticles of any material. Particles are measured one-by-one in MRPS, making possible the high-resolution analysis of complex polydisperse mixtures such as serum, urine and aggregating systems.
The nCS1 is a practical technique well-suited for routine industrial use. Analysis is performed in a disposable microfluidic cartridge and only 3 microliters of sample are required for analysis. Unlike other implementations of RPS, Spectradyne’s MRPS cartridges are optimized for nanoparticle measurements: for example through the inclusion of embedded microfluidic features that significantly reduce clogging events and enable robust measurements at high concentration. The cartridges also save operation time—no cleaning of flow cells is required between samples, and complete sample analysis is typically achieved in a few minutes.
Key Features of Spectradyne’s nCS1:
Typical Spectradyne nCS1 Applications are:
XiGo Nanotools particle technology measures the particle liquid interface of suspensions without dilution, providing a sensitive tool for research and development as well as quality assurance.
The surface area of particles influences many aspects of product performance such as the hiding power of pigments, the activity of catalysts, the taste of food, the potency of drugs and the bioavailability of drugs. In the past, surface area measurements were made using methods such as gas adsorption, mercury porosimetry, and gravimetric analysis. These methods all have the same limitation; they are only useful for analyzing dry powders.
However, the overwhelming majority of manufactured products involve dispersions of particles in a liquid, either in the final state or at some stage of production. While dry powder methods are suitable to test incoming dry powder raw materials, they cannot provide information about the particles when dispersed in a liquid. To date this has not been possible other than to estimate the surface area from particle size measurements or to perform time- consuming adsorption isotherm or titration measurements.
The XiGo Software is designed so that measurements can be performed with little operator training, making their technology accessible to R&D and QC/QA/in-Process applications. Xigo’s patented technology is based on nuclear magnetic resonance (NMR) and, although small in size, functions as a portable NMR machine, capable of a wide range of standard NMR tests in addition to surface area measurements. XiGo seeks to provide devices that help scientists, researchers and corporations improve the performance of nanomaterials ushering the transition of these materials from the research laboratory to commercial applications.
The Acorn Area is a revolutionary instrument designed to measure the surface area of nanoparticles dispersed in a liquid. This patented nuclear magnetic resonance based method offers many advantages in comparison with conventional surface area techniques.
Measurements take about 5 minutes from start to finish. No sample preparation such as drying or degassing is required. High concentration dispersions are measured directly; without dilution. Acorn Area measurements are orders of magnitude faster than any other surface area measuring technique.